I have make hand sanitizer and in this i have use carbomer 940 as a thickner agents but i am facing problem with 940. One of the most widely used carbomers however is carbomer 940. Gelcreams, hair gels, and other gels, lotions, creams. Carbomer not only thickens a product, but will bring stability and texture enhancement. United states pharmacopeianational formulary uspnf monograph for carbomer 940 general product characteristics appearance. I also bought some tea polyvinyl carboxy polymer which makes the carbomer solution more alkaline and causes it to thicken more. Sanitizer become very cloudy not transparent my question is i am mixing correct product or is there any substitutes for carbomer 940 thanks. Each gram of gel contains 2mg carbomer polyacrylic acid as the active ingredient. It is easier to add the active drug before the gel is formed if the drug doesnt interfere with the gel formation.
Acrylic polymers carbomer are a class of high molecular weight, watersoluble polymer and rheology modifier. Common gelling agents university of north carolina at. What carbomer looks like and contents of the pack carbomer is a clear sterile liquid gel. I have seen 940 used in various commercial aloe gels so i thought it might work with aloe. Properties comparison of various benzene grades of carbogel trade name carbogel carbogel 934 934p carbogel 940 carbogel 941 carbogel 42 polymer type homopolymer homopolymer homopolymer homopolymer copolymer assay % 5668 5668 5668 5668 5262 aqueous dispersion 0. An isopropyl alcohol gel having use as a rubbing composition and having antiseptic properties.
Carbomer 940 is a polyvinyl carboxy polymer used as a viscosity enhancer, gelling agent, or. For the thickener, i have carbomer 940, which is a polyvinyl carboxy polymer. Carbomer homopolymer type c former carbomer 940 by u. Behaviour of carbopol ultrez 10 hydrogels was studied in regard to the polymer concentration and ph of the gel. Hand sanitizer gel having important ingredients that are ethyl alcohol or isopropyl alcohol or together used in the same mixture,carbomer used for thickness, glycerine to protect hand outside,preservative agent to protect products etc.
Things to consider before you start to use carbomer 980 0. It is a viscosity modifier, stabilizer, dispersant and emulsifier. I used 940 because it is the cheapest, the other varieties are at least double the price. Carbopol 940 nf polymer product specifications lubrizol. When data for the primary subjective efficacy variables were stratified for disease severity, there was a statistically significant improvement from baseline by day 10 for severely affected patients and from day 42 for patients with moderate disease. Formulation and development ph induced insitu gelling system of. Carbomer is an extremely efficient rheology modifier capable of providing high viscosity and forms. Viscoelastic properties of carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases article pdf available in pharmaceutical research 2212. Carbomer 940 the key to easy formulation of gels and suspension products.
Formulation gel used carbopol 940 as gelling aget and sorbitol as humectant. Rheological characterization of topical carbomer gels. The polymer is dispersed in water to create a thick phase. Carbomers can be found in a wide variety of product types including skin. Slightly acetic test specification lot test frequency1.
Im finding that the carbomer tends to make your hands feel sticky just before the sanitizer is completely dried. As with any polyacrylatebased water thickener like carbopol 940, the key is to ensure you are at the correct ph. A novel method of radiolabelling carbomer gels, with minimum change to their rheology, has permitted. Carbomer pregel how to make a gel using carbomer 940 carbomer 940 is classed as a gelling agent and forms clear gels. Us5508029a isopropyl alcohol gel composition and process. Pdf viscoelastic properties of carbopol 940 gels and. Utilized in pharmaceutical products as rheology modifiers, tablet binders, suspension stabilizers, extended release polymers, mucoadhesive aids, and bioavailability enhancers, carbopol polymers are well known for their. Formulation and evaluation of topical herbal gel for the. By changing the usage level, you can create a stable free flowing product to a very stiff hair gel. Carbomer pre gel how to make a gel using carbomer 940 carbomer 940 is classed as a gelling agent and forms clear gels. Formulation and in vitro evaluation of carbopol 934based modified clotrimazole gel for topical application muhammad ubaid1, sadaf ilyas1, sadullah mir2, abida k.
Carbopol 940 nf polymer meets the limits cited in the current edition of the. Carbomer 940 should then be allowed to swellhydrate. Carbomer codes 910, 934, 940, 941, and 934p are an indication of molecular weight and the specific components of the polymer. Pdf rheological characterization of topical carbomer. Formulation and in vitro evaluation of carbopol 934based. Because of the way carbomer works, it is very rare for anybody to have any reaction to carbomer. Carbopol 940 is a polyvinyl carboxy polymer used as a viscosity enhancer or gelling agent. For many applications paas are used in form of alkali metal or ammonium salts, e.
The preferred polymer is a carbomer resin that forms a slightly gelatinous mass through hydration of the polymer. Carbopol ultrez 10 polymer can replace carbopol 940 polymer and carbopol 980 polymer for applications requiring easy processing and a carbomer inci name, such. I used polysorbate 80 because i read in an article that it could help hold the ipa in a carbomer gel, same reason i used pg. As threedimensionally crosslinked microgels, carbomers do not dissolve but swell to a remarkable extent in water after neutralization to form a gel. Transdermal gel formulation containing glibenclamide can be prepared by direct dispersion method, using carbopol 940 as a. It is a proven exceptional thickener, suspending agent and stabilizer utilized in a wide variety of personal care products. Hello every one, i did experiment on carbomer preparation, as iam a student, i did this experiment in my student lab, we did mistake by using hot water so hope you understand my practical, thumbs. The study concerns with the theological behaviour of carbopol940 hydrogel at different concentrations.
Carbomer is a term used for a series of polymers primarily made from acrylic acid. Since their creation as the first commercial carbomers over 50 years ago, lubrizols carbopol polymers have continued to be the highest quality carbomers on the market. Rheological characterization of topical carbomer gels neutralized to different ph article pdf available in pharmaceutical research 217. The primary objective of this study is to perform detailed and extensive rheological characterization of rheology. Carbomer is a homopolymer of acrylic acid crosslinked with an allyl ether of pentaerythritol, an allyl ether of sucrose, or an allyl ether of propylene. Thickner agents in hand sanitizer cosmetic science talk. The carbomer gel also significantly improved the rose bengal staining score relative to placebo.
Request pdf effects of carbomer 940 hydrogel on burn wounds. Backgroundaims carbomers are widely used in products for the treatment of dry eye. Carbomer base carbomer is a polymer that will swell when in contact with water. Find patient medical information for carbomer gelaqueous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This research aimed to determine the optimum composition of carbopol 940 and sorbitol and their interactions in determining the stability of gel, as well as to get the optimum area of antiacne gel formulation leaf extract binahong. Final report on the safety assessment of carbomers934. As with gums, carbomer 940 should be put into a dry container to which the amount of room temperature distilleddeionized water, in your formula, will be added.
It can be used to thicken the water for a lotion or making a gel base for a skin serum or hair styling. By studying the various rheological properties of carbopol gels under a. Rheological characterization of topical carbomer gels neutralized to different ph mohammad t. It is one of a group of eye drops called artificial tears. Carbomer for cosmetic use to thicken and viscosity adjust gel. Carbomer also contains the inactive ingredients cetrimide as a preservative, sorbitol, sodium hydroxide and water for injection. The socalled ultrasonic conducting gel or contact gel for ultrasound is an aqueous or hydroalcoholic gel of carbopol 940 to which more or less alcohol is added as desired more or less refreshing. This study was designed to investigate the applicability of carbomer 940 hydrogel on skin. Carbomers are white, fluffy powders but are frequently used as gels in cosmetics and personal care products. Carbomer is the main part of almost every cosmetics and pharmaceutical product which is offered as a gel, from cosmetic glitter gels to cuticle removers to gel toothpastes. Clear eye gel sample recipe for carbomer clear eye gel skin tightening and moisturizing phase a weight % for 50 g 1. Ocular contact time of a carbomer gel geltears in humans. Safety data sheet revision date 29apr2020 revision number 4 1. First carbomer on the market based on class 3 solvent nheptane ethylacetate, according to pharmacopoes.
Neutralization can be carried out with inorganic bases such as naoh or koh or triethanolamine tea. Solvent type, polymer concentration, gel preparation, mechanical properties. The carbomer polymers are used in cosmetics and emulsifying agents at concentrations up to 50%. The isopropyl alcohol gel of the present invention comprises a polymer, water, isopropyl alcohol and a polymer neutralizing agent. Uses advised against food, drug, pesticide or biocidal product use. The key to easy formulation of gels and suspension products. In addition, carbopol is used in the cosmetic industry. With that much ethanol, ph measurement can be difficult, so maybe take out the ethanol and see what the ph is or thickening power is without the etoh. Gel was stable, clarity was better than that with carbopol 940.
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